There are several disorders that have similar symptoms to Premenstrual Dysphoric Disorder (PMDD). Many are characterized by cycling moods, including severe depression. PMDD is often misdiagnosed as a result of the overlap in symptoms. 

A patient history that points to hormonally based depression:

  • A history of mild or severe PMS as a teenager
  • Relief of depressive symptoms during pregnancy
  • Postpartum depression, with new-onset or newly recurring depressive symptoms
  • Recurrence of premenstrual depression following resumption of menstruation after delivery
  • Worsening of premenstrual depression with age, blending into the menopausal transition and becoming less cyclical thereafter
  • Coexistence of cyclical somatic symptoms, such as menstrual migraine, bloating, or breast pain  which are not associated with bipolar disorder
  • Runs of 5 to 20 relatively stable mood state days per month
  • Recurrent episodes of depression, often severe and related to menstrual periods, but without episodes of mania